Flaherty Lab Publications

16.   Flaherty, D. P.*; Seleem, M. N.; Supuran, C. T. Bacterial Carbonic Anhydrases: Underexploited antibacterial therapeutic targetsFuture Medicinal Chemistry, 2021, Just Accepted. DOI: 10.4155/fmc-2021-0207 

15.   Nocentini, A.; Hewitt, C. S.; Mastrolorenzo, M. D.; Flaherty, D. P.*; Supuran, C. T.* Anion inhibition studies of the alpha-carbonic anhydrase from Neisseria gonorrhoeae. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36, 1061 - 1066. DOI: 10.1080/14756366.2021.1929202

14.   Hewitt, C.S; Abutaleb, N.S.; Elhassanny, A.E.M.; Nocentini, A.; Cao, X.; Amo, D.P.; Youse, M.S.; Holly, K.J.; Marapaka, Anil Kumar; An, W.; Kaur, J.; Krabill, A.D.; Elkashif, A.; Elgammal, Y.; Graboski, A.L.; Supuran, C.T.; Saleem, M.N.*, Flaherty, D.P.* Structure-activity relationship studies of acetazolamide-based inhibitors with activity against Neisseria gonorrhoeae. ACS Infectious Diseases,  2021, Just accepted. DOI: 10.1021/acsinfecdis.1c00055.

13.   Chojnacki, M.; Cao, X.; Flaherty, D.P.* and Dunman, P.D.* Optimization of 2-acylaminocycloalkythiophene derivatives for activity against Staphylococcus aureusAntibiotics, 2021, 10, 369 

12.   Krabill, A.D.; Chen, H.; Hussain, S.; Hewitt, C.S.; Imhoff, R.D.; Muli, C.S.; Das, C.; Galardy, P.J.; Wendt, M.K.; Flaherty, D.P.; Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.  Molecules, 2021, 26(5), p.1227.

11.  Sheedlo, M. J.; Kenny, S.; Podkoytov, I. S.; Brown, K.; Ma, J.; Iyer, S.; Hewitt, C. S.; Arbough, T.; Mikhailovskii, O.; Flaherty D. P.; Wilson, M. A.; Skrynnikov, N. R.; Das, C. Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA. Biochemistry,2021, just accepted, DOI:10.1021/acs.biochem.0c00760
10.  Abutaleb, N. S.; Elhassanny, A. E. M.; Flaherty, D. P.; Seleem, M. N. In vitro and in vivo activities of carbonic anhydrase inhibitor, dorzolamide, against vancomycin-resistant enterococci. PeerJ, 2021, 9, e11059
9.  Abutaleb, N. S.; Elkashif, A.; Flaherty, D. P.; Seleem, M. N. In vivo antibacterial activity of acetazolamide. Antimicrobial Agents and Chemotherapy, 2021, 65, e01715-20. DOI: 10.1128/AAC.01715-20
8. Hewitt, C. S.; Krabill, A. D.; Das, C.; Flaherty, D. P. Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinase. Biochemistry, 2020, 59 (37), 3447 – 3462

7.  Kaur, J.; Cao, X.; Abutaleb, N. S.; Elkashif, A.; Graboski, A. L.; Krabill, A. D.; AbdelKhalek, A. H.; An, W.; Bhardwaj, A.; Seleem, M. N.; Flaherty, D. P. Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus. Journal of Medicinal Chemistry, 2020, 63(17), 9540-9562. DOI:10.1021/acs.jmedchem.0c00734.

6.  Chojnacki, M.; Cao, X.; Young, M.; Fritz, R.; Dunman, P. M.; Flaherty, D. P. Optimization of 4-substituted Benzensulfonamide Scaffold to Reverse Acinetobacter baumannii Serum-Adaptive Efflux Associated Antibiotic Tolerance. ChemMedChem, 2020, 15 (18), 1731-1740. DOI: 10.1002/cmdc/202000328.

4.   Krabill, A.D., Chen, H., Hussain, S., Feng, C., Abdullah, A., Hewitt, C.S.; Das, C., Aryal, U.K., Post, C.B., Wendt, M.K., Galardy, P.J. and Flaherty, D.P.Ubiquitin C-terminal hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine-Based Inhibitor. ChemBioChem,2020, 21, 712-722.

3.     Colquhoun, J. M.; Ha, L.; Beckley, A.; Meyers, B.; Flaherty, D. P.; Dunman, P. M.; Identification of Small Molecule Inhibitors of Staphylococcus aureus RnpA. Antibiotics, 2019, 8 (48).
2.     Kaur, J.; Soto-Velasquez, M.; Ding, Z.; Ghanbarpour, A.; Lill, M. A.; van Rijn, R. M.; Watts, V. J.; Flaherty, D. P. Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain. European Journal of Medicinal Chemistry, 2018, 162, 568 - 585.
1.     Ha, L; Colquhoun, J.; Noinaj, N.; Das, C.; Dunman, P. M.; Flaherty, D. P.  Crystal Structure of the ribonuclease P protein subunit from Staphylococcus aureus. Acta Crystallographica Section F. 2018, 74, 632 - 637.